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| Player | Eligible to Return | Actual Status/Prognosis | | Michel Hernandez | 0000-00-00 | Fractured right finger - out 4-6 weeks |
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| Player | Eligible to Return | Actual Status/Prognosis | | Edinson Volquez | 2010-04-25 | Recovery from right elbow surgery |
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| Player | Eligible to Return | Actual Status/Prognosis | | Anthony Reyes | 2010-04-25 | Recovery from right elbow surgery |
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| Player | Eligible to Return | Actual Status/Prognosis | | Huston Street | 0000-00-00 | Tightness in right shoulder |
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| Player | Eligible to Return | Actual Status/Prognosis | | Lance Berkman | 0000-00-00 | Left knee surgery - out 2-4 weeks |
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| Player | Eligible to Return | Actual Status/Prognosis | | Henry Barrera | 2010-05-02 | Recovery from right elbow surgery |
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| Player | Eligible to Return | Actual Status/Prognosis | | Cory Wade | 0000-00-00 | Right shoulder surgery |
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| Player | Eligible to Return | Actual Status/Prognosis | | Jose Reyes | 0000-00-00 | Thyroid imbalance - out 6-8 weeks |
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| Player | Eligible to Return | Actual Status/Prognosis | | Desmond Jennings | 0000-00-00 | Sprained left wrist - out 2-3 weeks |
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| Player | Eligible to Return | Actual Status/Prognosis | | Eric Hurley | 2010-05-12 | Recovery from right shoulder surgery |
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| Player | Eligible to Return | Actual Status/Prognosis | | Dirk Hayhurst | 2010-04-24 | Right shoulder surgery - out 4-6 months | | Jesse Litsch | 2010-04-27 | Recovery from right elbow surgery | | Scott Richmond | 2010-05-03 | Right shoulder impingement |
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| Player | Eligible to Return | Actual Status/Prognosis | | Jordan Zimmermann | 2010-04-20 | Recovery from right elbow surgery |
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